منابع مشابه
Phytosome: Drug Delivery System for Polyphenolic Phytoconstituents
Several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro, demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or destruction in gut. Drug delivery system for polyphenolic phytoconstituents (phytosomes) was prepared by complexing polyphenolic phytoconstituents with phospholipid mainly phosphatidylcholine wh...
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The delivery of drugs and bioactive compounds via the lymphatic system is complex and dependent on the physiological uniqueness of the system. The lymphatic route plays an important role in transporting extracellular fluid to maintain homeostasis and in transferring immune cells to injury sites, and is able to avoid first-pass metabolism, thus acting as a bypass route for compounds with lower b...
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The lymphatic system consists of lymph, lymphatic pathways such as lymphatic capillary, lymphatic vessel, lymphatic duct etc., and some lymphatic organs including lymph node, thymus, and spleen. The delivery of drugs and bioactive compounds via the lymphatic system is dependent on the physiology of the system. The lymphatic system is able to avoid first-pass metabolism, thus the lymphatic syste...
متن کاملAdvances in lymphatic imaging and drug delivery.
Cancer remains the second leading cause of death after heart disease in the US. While metastasized cancers such as breast, prostate, and colon are incurable, before their distant spread, these diseases have invaded the lymphatic system as a first step in their progression. Hence, proper evaluation of the disease state of the lymphatics which drain a tumor site is crucial to staging and the form...
متن کاملSelf-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake
Huperzine A (Hup-A) is a poorly water-soluble drug with low oral bioavailability. A self-microemulsifying drug delivery system (SMEDDS) was used to enhance the oral bioavailability and lymphatic uptake and transport of Hup-A. A single-pass intestinal perfusion (SPIP) technique and a chylomicron flow-blocking approach were used to study its intestinal absorption, mesenteric lymph node distributi...
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ژورنال
عنوان ژورنال: International Journal of Advances in Pharmacy and Biotechnology
سال: 2020
ISSN: 2454-8375
DOI: 10.38111/ijapb.20200602003